https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Severe asthma ILC2s demonstrate enhanced proliferation that is modified by biologics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50840 Wed 28 Feb 2024 16:33:00 AEDT ]]> Regional variation in prevalence of difficult-to-treat asthma and oral corticosteroid use for patients in Australia: heat map analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52775 Wed 28 Feb 2024 16:20:21 AEDT ]]> The Complex Association between COPD and COVID-19 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51290 Wed 28 Feb 2024 16:16:24 AEDT ]]> Airway inflammatory changes in the lungs of patients with asthma-COPD overlap (ACO): a bronchoscopy endobronchial biopsy study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52688 Wed 28 Feb 2024 15:49:25 AEDT ]]> Differential airway remodeling changes were observed in patients with asthma COPD overlap compared to patients with asthma and COPD alone https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51924 Wed 28 Feb 2024 09:57:50 AEDT ]]> Comparison of commercially available differentiation media on cell morphology, function, and anti-viral responses in conditionally reprogrammed human bronchial epithelial cells. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52054 Wed 27 Sep 2023 15:30:47 AEST ]]> Serum prednisolone levels as a marker of oral corticosteroid adherence in severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45112 Wed 26 Oct 2022 13:25:03 AEDT ]]> Diagnosis and investigation in the severe asthma clinic https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29970 Wed 24 Nov 2021 15:50:33 AEDT ]]> Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55346 Wed 22 May 2024 12:26:00 AEST ]]> Asthma-COPD overlap: current understanding and the utility of experimental models https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43527 Wed 21 Sep 2022 11:32:49 AEST ]]> Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50107 Wed 12 Jul 2023 13:43:56 AEST ]]> Recent advances in understanding and managing asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29776 Wed 11 Apr 2018 15:54:23 AEST ]]> Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22168 -/-) BALB/c mice were intranasally sensitised and challenged with HDM prior to infection with RV1B. In some experiments, mice were administered recombinant IFN or adoptively transferred with plasmacytoid dendritic cells (pDC). Results: Allergic Tlr7-/- mice displayed impaired IFN release upon RV1B infection, increased virus replication and exaggerated eosinophilic inflammation and airways hyper reactivity. Treatment with exogenous IFN or adoptive transfer of TLR7-competent pDCs blocked these exaggerated inflammatory responses and boosted IFNγ release in the absence of host TLR7 signalling. TLR7 expression in the lungs was suppressed by allergic inflammation and by interleukin (IL)-5-induced eosinophilia in the absence of allergy. Subjects with moderate-to-severe asthma and eosinophilic but not neutrophilic airways inflammation, despite inhaled steroids, showed reduced TLR7 and IFNλ2/3 expression in endobronchial biopsies. Furthermore, TLR7 expression inversely correlated with percentage of sputum eosinophils. Conclusions: This implicates IL-5-induced airways eosinophilia as a negative regulator of TLR7 expression and antiviral responses, which provides a molecular mechanism underpinning the effect of eosinophil-targeting treatments for the prevention of asthma exacerbations.]]> Wed 11 Apr 2018 15:36:21 AEST ]]> Innate immunity and immune evasion by Enterovirus 71 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22590 Wed 11 Apr 2018 14:56:27 AEST ]]> Pregnant women have attenuated innate interferon responses to the 2009 pandemic influenza A virus subtype H1N1 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14141 Wed 11 Apr 2018 14:22:02 AEST ]]> Plasmacytoid dendritic cells and CD8 T cells from pregnant women show altered phenotype and function following H1N1/09 infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14145 Wed 11 Apr 2018 13:46:42 AEST ]]> Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30281 Fbln1c protected against CS-induced airway fibrosis and emphysema-like alveolar enlargement. In experimental COPD, this occurred through disrupted collagen organization and interactions with fibronectin, periostin, and tenascin-c. Genetic inhibition of Fbln1c also reduced levels of pulmonary inflammatory cells and proinflammatory cytokines/chemokines (TNF-a, IL-33, and CXCL1) in experimental COPD. Fbln1c⌿ mice also had reduced airway remodeling in experimental chronic asthma and pulmonary fibrosis. Our data show that Fbln1c may be a therapeutic target in chronic respiratory diseases.]]> Wed 11 Apr 2018 13:33:47 AEST ]]> Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15132 Wed 11 Apr 2018 12:40:17 AEST ]]> Innate immunity in the airways to respiratory viruses https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20766 Wed 11 Apr 2018 11:14:18 AEST ]]> Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14773 Wed 11 Apr 2018 11:04:31 AEST ]]> Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14143 Wed 11 Apr 2018 09:25:13 AEST ]]> A prospective study of respiratory viral infection in pregnant women with and without asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14664 Wed 04 Sep 2019 11:10:47 AEST ]]> CD8 T cells and dendritic cells: key players in the attenuated maternal immune response to influenza infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21107 Wed 04 Sep 2019 10:31:12 AEST ]]> Inflammatory and anti-viral responses to influenza A virus infection are dysregulated in pregnant mice with allergic airway disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52146 Wed 04 Oct 2023 10:20:41 AEDT ]]> Respiratory viruses and asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35004 Wed 02 Mar 2022 14:28:06 AEDT ]]> Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37457 Wed 02 Mar 2022 14:26:12 AEDT ]]> Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30800 Wed 02 Mar 2022 14:24:09 AEDT ]]> An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44806 Wed 01 May 2024 12:05:04 AEST ]]> Endoplasmic reticulum-unfolded protein response signalling is altered in severe eosinophilic and neutrophilic asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49760 Tue 30 May 2023 18:39:10 AEST ]]> Conditionally reprogrammed asthmatic bronchial epithelial cells express lower FOXJ1 at terminal differentiation and lower IFNs following RV-A1 infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47290 Tue 30 Apr 2024 08:50:07 AEST ]]> TLR2-mediated innate immune priming boosts lung anti-viral immunity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48671 Tue 28 Mar 2023 10:25:49 AEDT ]]> The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43636 Tue 27 Sep 2022 09:39:17 AEST ]]> The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52014 Tue 26 Sep 2023 11:42:59 AEST ]]> Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID-OLE) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34534 Tue 26 Mar 2019 12:02:33 AEDT ]]> Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39820 Tue 26 Jul 2022 11:33:21 AEST ]]> Neisseria species as pathobionts in bronchiectasis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53306 Tue 21 Nov 2023 12:03:02 AEDT ]]> Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48579 Tue 21 Mar 2023 17:43:58 AEDT ]]> ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46351 n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. Results: Increased gene expression of ACE2 was associated with older age (P = 0.03) and male sex (P = 0.03), but not with pack-years smoked. When we compared gene expression between adults with asthma, COPD and healthy controls, mean ACE2 expression was lower in asthma patients (P = 0.01). Gene expression of furin, a protease that facilitates viral endocytosis, was also lower in patients with asthma (P = 0.02), while ADAM-17, a disintegrin that cleaves ACE2 from the surface, was increased (P = 0.02). ACE2 protein expression was also reduced in endobronchial biopsies from asthma patients. Conclusion: Increased ACE2 expression occurs in older people and males. Asthma patients have reduced expression. Altered ACE2 expression in the lower airway may be an important factor in virus tropism and may in part explain susceptibility factors and why asthma patients are not over-represented in those with COVID-19 complications.]]> Tue 15 Nov 2022 15:15:58 AEDT ]]> Molecular markers of type 2 airway inflammation are similar between eosinophilic severe asthma and eosinophilic chronic obstructive pulmonary disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49105 Tue 14 Nov 2023 14:40:06 AEDT ]]> Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43133 Tue 13 Sep 2022 15:14:32 AEST ]]> Mepolizumab and Oral Corticosteroid Stewardship: Data from the Australian Mepolizumab Registry https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47085 Tue 13 Dec 2022 16:35:23 AEDT ]]> Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47013 Tue 13 Dec 2022 11:48:24 AEDT ]]> Severe asthma: current management, targeted therapies and future directions-a roundtable report https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33751 Tue 08 Jan 2019 15:37:34 AEDT ]]> Upper Respiratory Tract OC43 Infection Model for Investigating Airway Immune-modifying Therapies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54163 Tue 06 Feb 2024 13:06:40 AEDT ]]> Time-resolved proteomic profiling of cigarette smoke-induced experimental chronic obstructive pulmonary disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43823 Tue 04 Oct 2022 11:04:24 AEDT ]]> A randomised trial of hypertonic saline during hospitalisation for exacerbation of cystic fibrosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30031 Thu 28 Oct 2021 13:04:21 AEDT ]]> Advances in the treatment of virus-induced asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27734 Thu 28 Oct 2021 13:04:05 AEDT ]]> Contemporary Concise Review 2019: Asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41149 Thu 28 Jul 2022 09:13:20 AEST ]]> IL-25 blockade augments antiviral immunity during respiratory virus infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45347 Thu 27 Oct 2022 17:08:36 AEDT ]]> Nasal epithelial cells to assess in vitro immune responses to respiratory virus infection in pregnant women with asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45097 Thu 27 Oct 2022 13:58:29 AEDT ]]> Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38305 Thu 26 Aug 2021 11:11:37 AEST ]]> The genetic and epigenetic landscapes of the epithelium in asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29462 IRAKM, PCDH1, ORMDL3/GSDMB, IL-33, CDHR3 and CST1 in airway epithelial cells. Recent studies on epigenetic regulatory factors have further provided novel insights to the field, particularly their effect on regulation of some of the asthma susceptibility genes (e.g. methylation of ADAM33). Among the epigenetic regulatory mechanisms, microRNA networks have been shown to regulate a major portion of post-transcriptional gene regulation. Particularly, miR-19a may have some therapeutic potential.]]> Thu 24 Mar 2022 11:32:30 AEDT ]]> The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22003 Thu 23 Aug 2018 11:26:32 AEST ]]> Clinical Subtypes of Neutrophilic Asthma: A Cluster Analysis From Australasian Severe Asthma Network https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54912 Thu 21 Mar 2024 12:03:37 AEDT ]]> Severe asthma assessment, management and the organisation of care in Australia and New Zealand: expert forum roundtable meetings https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39023 Thu 21 Apr 2022 09:51:00 AEST ]]> Sputum transcriptomics implicates increased p38 signalling activity in severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46113 n = 12, defined as per GINA criteria), non-severe uncontrolled (n = 21) and controlled asthma (n = 21) and healthy controls (n = 15). Sputum RNA was extracted and transcriptomic profiles were generated (Illumina HumanRef-8 V2) and analysed (GeneSpring). Sputum protein lysates were analysed for p38 activation in a validation study (n = 24 asthma, n = 8 healthy) by western blotting. Results: There were 2166 genes differentially expressed between the four groups. In severe asthma, the expression of 1875, 1308 and 563 genes was altered compared to healthy controls, controlled and uncontrolled asthma, respectively. Of the 1875 genes significantly different to healthy controls, 123 were >2-fold change from which four networks were identified. Thirty genes (>2-fold change) were significantly different in severe asthma compared to both controlled asthma and healthy controls. There was enrichment of genes in the p38 signalling pathway that were associated with severe asthma. Phosphorylation of p38 was increased in a subset of severe asthma samples, correlating with neutrophilic airway inflammation. Conclusion: Severe asthma is associated with substantial differences in sputum gene expression that underlie unique cellular mechanisms. The p38 signalling pathway may be important in the pathogenesis of severe asthma, and future investigations into p38 inhibition are warranted as a ‘non-Th2’ therapeutic option.]]> Thu 18 Apr 2024 11:56:00 AEST ]]> Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34512 Thu 17 Mar 2022 14:40:35 AEDT ]]> Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29745 9/L vs 0.15×109/L; P<0.0001). Blood eosinophils correlated with both the percentage (ρ=0.535; P<0.0001) and number of sputum eosinophils (ρ=0.473; P<0.0001). Absolute blood eosinophil count was predictive of sputum eosinophilia (area under the curve =0.76, 95% confidence interval [CI] =0.67–0.84; P<0.0001). At a threshold of ≥0.3×10/L (specificity =76%, sensitivity =60%, and positive likelihood ratio =2.5), peripheral blood eosinophil counts enabled identification of the presence or absence of sputum eosinophilia in 71% of the cases. A threshold of ≥0.4×109/L had similar classifying ability but better specificity (91.7%) and higher positive likelihood ratio (3.7). In contrast, ≥0.2×109/L offered a better sensitivity (91.1%) for ruling out sputum eosinophilia. There was a good agreement between two measurements of blood eosinophil count over a median of 28 days (intraclass correlation coefficient =0.8; 95% CI =0.66–0.88; P<0.0001). Conclusion: Peripheral blood eosinophil counts can help identify the presence or absence of sputum eosinophilia in stable COPD patients with a reasonable degree of accuracy.]]> Thu 17 Feb 2022 09:29:13 AEDT ]]> Transcriptomics of biopsies identifies novel genes and pathways linked to neutrophilic inflammation in severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48843 ±2) including genes associated with innate immunity response, neutrophil degranulation and IL-10 signalling. NA presented enrichment to pathways previously linked to neutrophilic inflammation; dendritic cell maturation, Th1, TREM1, inflammasome, Th17 and p38 MAPK, as well as novel links to neuroinflammation, NFAT and PKCθ signalling. EA presented similar transcriptomic profiles to PGA and HC. Despite the higher proportion of bacterial colonization in NA, no changes were observed in the transcriptomic profiles of severe asthma culture positive compared with severe asthma culture negative. Conclusions & Clinical Relevance: NA features a distinct transcriptomic profile with seven pathways enriched in NA compared to EA, PGA and HC. All those with severe asthma had significant enrichment for SUMOylation, basal cell carcinoma signalling and Wnt/β-catenin pathways compared to HC, despite high-dose inhaled corticosteroids. These findings contribute to the understanding of mechanistic pathways in endobronchial biopsies associated with NA and identify potential novel treatment targets for severe asthma.]]> Thu 13 Apr 2023 09:45:44 AEST ]]> Antiviral immunity is impaired in COPD patients with frequent exacerbations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36808 Thu 04 Nov 2021 10:39:56 AEDT ]]> Pathogenesis, clinical features of asthma COPD overlap, and therapeutic modalities https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46830 Thu 01 Dec 2022 11:45:24 AEDT ]]> Blocking notch3 signaling abolishes MUC5AC production in airway epithelial cells from individuals with asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46730 Thu 01 Dec 2022 10:28:14 AEDT ]]> Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14142 Sat 24 Mar 2018 08:24:51 AEDT ]]> Innate immunity to influenza in chronic airways diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16017 Sat 24 Mar 2018 08:19:30 AEDT ]]> Airway epithelial and early innate immune responses to virus infections https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17439 Sat 24 Mar 2018 08:01:35 AEDT ]]> The interaction between mother and fetus and the development of allergic asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20875 Sat 24 Mar 2018 07:57:57 AEDT ]]> Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19878 Sat 24 Mar 2018 07:57:00 AEDT ]]> Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27228 Sat 24 Mar 2018 07:32:23 AEDT ]]> The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22271 Sat 24 Mar 2018 07:17:40 AEDT ]]> Airway epithelial cell immunity is delayed during rhinovirus infection in asthma and COPD https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38585 in vitro airway epithelial infection models using high multiplicity of infection (MOI) and lacking genome-wide, time course analyses have obscured the role of epithelial innate anti-viral immunity in asthma and COPD. To address this, we developed a low MOI rhinovirus model of differentiated primary epithelial cells obtained from healthy, asthma and COPD donors. Using genome-wide gene expression following infection, we demonstrated that gene expression patterns are similar across patient groups, but that the kinetics of induction are delayed in cells obtained from asthma and COPD donors. Rhinovirus-induced innate immune responses were defined by interferons (type-I, II, and III), interferon response factors (IRF1, IRF3, and IRF7), TLR signaling and NF-κB and STAT1 activation. Induced gene expression was evident at 24 h and peaked at 48 h post-infection in cells from healthy subjects. In contrast, in cells from donors with asthma or COPD induction was maximal at or beyond 72–96 h post-infection. Thus, we propose that propensity for viral exacerbations of asthma and COPD relate to delayed (rather than deficient) expression of epithelial cell innate anti-viral immune genes which in turns leads to a delayed and ultimately more inflammatory host immune response.]]> Mon 29 Jan 2024 18:03:54 AEDT ]]> Why are people with asthma more susceptible to influenza? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46666 Mon 28 Nov 2022 18:39:29 AEDT ]]> The effects of increasing fruit and vegetable intake in children with asthma: A randomized controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39780 Mon 25 Jul 2022 11:26:17 AEST ]]> Understanding the Unfolded Protein Response in the Pathogenesis of Asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47533 Mon 23 Jan 2023 12:22:34 AEDT ]]> Lumacaftor/ Ivacaftor improves ese tolerance in patients with cystic fibrosis and severe airflow obstructionxerci https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46958 40% predicted. We set out to observe the most sensitive clinical measure that would change with treatment in terms of exercise capacity or lung function in adults with severe lung disease as defined by an FEV1 < 40% predicted when clinically stable. Methods: 10 adults homozygous for the Phe508del received LUM/IVA. We assessed; six minute walk test (6MWT), spirometry, gas transfer (DLCO), plethysmography, and nitrogen multiple breath washout (MBW) at baseline, 4, 12, 24 and 52 weeks. Comparison was made with 10 matched historical controls that had been observed over 12 months. Results: There was a significant improvement in 6MWT by 4 weeks of treatment; with a mean increase of 78 m (SD 62.3) and this increased to 118.1 m (SD 80.9) (ANOVA p = 0.006) by 52 weeks. Significant improvements were also seen in the resting heart rate and the oxygen saturation (SaO2) after 6 min walking. A significant improvement was not seen in FEV1 though until 24 weeks, though this was maintained at 52 weeks (ANOVA, p = 0.0004). There were no significant differences seen in the MBW or DLCO. After 12 months treatment with LUM/IVA, in comparison to historical controls; the 6MWT increased by 118 m (SD 80.9), but fell in the controls - 61.3 m (SD 31.1). FEV1; LUM/IVA led to an increase of 0.398 L/min, compared to a fall in the controls - 0.18 (SD 0.2). Conclusion: In adults homozygous for Phe508del with severe disease, treatment with LUM/IVA results in a clinically significant improvement in 6MWT that was evident at 4 weeks and maintained at 52 weeks. Improvement in exercise tolerance is an important outcome to consider in those with more severe airways disease. Trial registration: This was an observational trial conducted on individuals who became eligible to receive LUM/IVA. All investigations were carried out as part of routine clinical care. The trial was registered in retrospect on the 13/5/2019 on the Australian New Zealand Clinical Trials registry; ACTRN12619000708156.]]> Mon 12 Dec 2022 10:01:33 AEDT ]]> Targeting treatable traits in severe asthma: a randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44178 Mon 10 Oct 2022 10:20:29 AEDT ]]> Association of Islet Amyloid Polypeptide to C-Peptide Ratio with Cystic Fibrosis-Related Diabetes: A Prospective Cross-sectional Study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52281 Mon 09 Oct 2023 10:04:55 AEDT ]]> Severe asthma toolkit: an online resource for multidisciplinary health professionals–needs assessment, development process and user analytics with survey feedback https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40572 Mon 08 Aug 2022 15:11:18 AEST ]]> Rhinovirus-induced CCL17 and CCL22 in asthma exacerbations and differential regulation by STAT6 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41052 Mon 08 Aug 2022 14:57:26 AEST ]]> Faecal microbial transfer and complex carbohydrates mediate protection against COPD https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55080 Mon 08 Apr 2024 14:10:40 AEST ]]> Ventilation heterogeneity is a treatable trait in severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55058 Mon 08 Apr 2024 09:43:57 AEST ]]> Appropriate use of oral corticosteroids for severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43398 Mon 04 Sep 2023 13:18:03 AEST ]]> Understanding Clinicians’ Perceived Barriers and Facilitators to Optimal Use of Acute Oxygen Therapy in Adults https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41270 Mon 01 Aug 2022 09:49:29 AEST ]]> Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48427 Fri 26 Apr 2024 13:31:04 AEST ]]> Type 2 Immunity and Its Impact on COVID-19 Infection in the Airways https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51945 Fri 22 Sep 2023 16:57:22 AEST ]]> Mepolizumab effectiveness and identification of super-responders in severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40118 Fri 22 Jul 2022 13:48:23 AEST ]]> Hypoxia-inducible factor and bacterial infections in chronic obstructive pulmonary disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40012 Streptococcus pneumoniae, Haemophilus influenzae and Pseudomonas aeruginosa)to induce infection in both the respiratory and gastroin-testinal (GI) tracts. However, the importance and mechanism of HIF-1αin augmenting PAFR-dependent bacterial infections in COPD are poorly understood. Here, we review the evidence for the roles of local tissue hypoxia-induced inflammation, HIF-1α and PAFR in facilitating bacterial infections in COPD. Blocking PAFR may provide a novel antimicrobial approach to manage bacterial infections in COPD.]]> Fri 22 Jul 2022 13:06:35 AEST ]]> Assessing the unified airway hypothesis in children via transcriptional profiling of the airway epithelium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37632 Fri 21 Jan 2022 09:39:15 AEDT ]]> Effects of fruit and vegetable consumption on inflammatory biomarkers and immune cell populations: a systematic literature review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37059 Fri 21 Aug 2020 11:53:43 AEST ]]> Management of acute COPD exacerbations in Australia: Do we follow the guidelines? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49505 Fri 19 May 2023 14:07:55 AEST ]]> Randomised controlled trial for the titration of oral corticosteroids using markers of inflammation in severe asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53104 Fri 17 Nov 2023 11:38:03 AEDT ]]> Gasping for sulfide: A critical appraisal of hydrogen sulfide in lung disease and accelerated aging https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49363 Fri 12 May 2023 12:42:28 AEST ]]> Microbiomic Analysis on Low Abundant Respiratory Biomass Samples; Improved Recovery of Microbial DNA From Bronchoalveolar Lavage Fluid https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41784 Fri 12 Aug 2022 12:10:18 AEST ]]> Acute oxygen therapy: a review of prescribing and delivery practices https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30102 Fri 11 Jun 2021 13:30:23 AEST ]]> A sputum 6 gene expression signature predicts inflammatory phenotypes and future exacerbations of COPD https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38377 Fri 10 Sep 2021 12:38:35 AEST ]]> Mechanical forces suppress antiviral innate immune responses from asthmatic airway epithelial cells following rhinovirus infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51239 Fri 10 Nov 2023 07:15:55 AEDT ]]> Human coronaviruses 229E and OC43 replicate and induce distinct antiviral responses in differentiated primary human bronchial epithelial cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41554 Fri 05 Aug 2022 14:23:21 AEST ]]> Mechanisms and management of asthma exacerbations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45534 Fri 04 Nov 2022 14:45:29 AEDT ]]> Treatable traits can be identified in a severe asthma registry and predict future exacerbations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37892 Fri 01 Apr 2022 09:25:28 AEDT ]]> Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30658 Fri 01 Apr 2022 09:24:25 AEDT ]]> Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36583 Fri 01 Apr 2022 09:23:30 AEDT ]]>